Syndrome of Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE)

Fatma Paksoy, Turgay Ulaş, Emrah Erkan Mazı, Ayda Batuan Damar, Fatih Borlu

Şişli Etfal Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İstanbul, Turkey

Keywords: Pitting edema, seronegative, symmetric arthritis, synovitis

Abstract

RS3PE (remitting seronegative, symmetric synovitis with pitting edema) is a benign, seronegative syndrome, with an acute onset of pitting edema on the dorsum of both hands and feet, which affects predominantly peripheral joints such as wrists and ankles symmetrically. A 58-year-old man presented with acute symmetrical polysynovitis of the wrists and ankles associated with pitting edema on the dorsum of the both hands and feet. He responded well to low-dose corticosteroids. There was no evidence of erosion radiologically. The clinical manifestations of the patient were consistent with RS3PE syndrome. Here, we present a case of RS3PE and review the literature. (Turk J Rheumatol 2010; 25: 88-90)