Cathepsin G and Its Role in Inflammation and Autoimmune Diseases

Siming GAO, Honglin ZHU, Xiaoxia ZUO, Hui LUO

Department of Rheumatology, Xiangya Hospital, Hunan, China

Keywords: Autoimmune disease; cathepsin G; immune reaction; inflammation

Abstract

Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that cathepsin G has important effects on inflammation and immune reaction, and may be a key factor in the pathogenesis of some autoimmune diseases. In this article, we discuss the roles of cathepsin G in inflammation, immune reaction, and autoimmune diseases. To our knowledge, this is the first study providing important information about cathepsin G in the pathogenesis of autoimmune diseases and suggesting that cathepsin G may be a new biomarker or treatment target.

Citation: Gao S, Zhu H, Zuo X, Luo H. Cathepsin G and its role in inflammation and autoimmune diseases. Arch Rheumatol 2018;33(4):498-504.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

This work was supported by grants from National Natural Science Foundation of China (81373206, 81401357), National High Technology Research and Development Program of China (2012AA02A513), Hunan Natural Science Foundation (13JJ5010), Hunan Special Fund for Science and Technology Development Program (2013WK3022), and Independent Innovation Projects of Central South University (2016zzts131).