IS LEPTIN A DETERMINANT OF BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS?
Günşah Şahin1, Hayal Güler1, Melek Sezgin1, Gürbüz Polat2
1Department of Physical Medicine and Rehabilitation, Mersin University, School of Medicine
2Department of Biochemistry , Mersin University, School of Medicine
Keywords: Leptin, Bone mineral density, Post Menopausal Osteoporosis
In this study, we aimed to investigate the serum leptin level whether it is a determinant of bone mineral density (BMD) in osteoporotic postmenopausal women. Forty (40) osteoporotic female patients (screened according to WHO criteria, tscore < 2.5SD, at lumbar region or femoral neck region) and forty (40) age and body mass index matched healthy female subjects(served as control group;t score >-1.0 ) were studied. All the women were at post-menopausal period. Serum concentrations of leptin after an overnight fast were measured by radioimmunoassay. BMD values were measured by dual energy X-ray absorptiometry (DEXA, NORLAND XR-46 ) at the lumbar spine, femoral neck and total body. There was no significant difference between groups regarding serum leptin levels (P=0.599).
Our study showed that there was no statistically significant difference concerning serum leptin levels in osteoporotic and non-osteoporotic postmenopausal women . However, at a local tissue level, leptin may effect bone. For this reason, leptin related studies at the bone micro-environment are promising.