Evaluation of adipokines, oxidative stress, and inflammatory markers in gout patients
Fatma Ozer1
, Fatih Baygutalp1, Muhammet Celik2, Nurcan Kılıc Baygutalp3
1Department of Physical Medicine and Rehabilitation, Atatürk University Faculty of Medicine, Erzurum, Türkiye
2Department of Medical Biochemistry, Atatürk University Faculty of Medicine, Erzurum, Türkiye
3Department of Biochemistry, Atatürk University Faculty of Pharmacy, Erzurum, Türkiye
Keywords: Gout, interleukin-10, irisin, oxidative stress.
Abstract
Objectives: This study aims to investigate the role of adipokines, oxidative stress, and inflammatory markers in the pathogenesis of gout.
Patients and methods: Between September 2021 and December 2022, a total of 88 volunteers including 44 patients (37 males, 7 females; mean age: 56.5±11.6 years; range, 30 to 77 years) with gout disease and 44 age- and sex-matched healthy controls (37 males, 7 females; mean age: 54.3±12.1 years; range, 30 to 78 years) were retrospectively analyzed. Serum interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), irisin, resistin, total oxidant status (TOS), and total antioxidant status (TAS) levels were analyzed.
Results: The mean serum irisin levels were significantly higher in patients with gout than in the healthy controls (405.6±97.3 and 316.0±80.8 pg/mL, respectively). The mean IL-10 levels were significantly lower in patients with gout than in healthy controls (90.8±71.9 and 172.7±128.6 pg/mL, respectively). There was no statistically significant difference in the serum resistin, TNF-α, TOS, or TAS levels between the groups (p>0.05).
Conclusion: Our study results show that serum irisin and IL-10 seem to be candidate biomarkers of diagnosis of gout.
Citation: Ozer F, Baygutalp F, Celik M, Kılıc Baygutal N. Evaluation of adipokines, oxidative stress, and inflammatory markers in gout patients. Arch Rheumatol 2025;40(1):112-122. doi: 10.46497/ ArchRheumatol.2025.11001.
Idea/concept, design, references and fundings, writing the article: F.Ö., F.B.; Control/supervision: F.B.; Data collection and/or processing: F.Ö., F.B, M.Ç.; Analysis and/or interpretation: M.Ç., N.K.B.; Critical review: F.B., N.K.B.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
This research was supported by the Atatürk University Scientific Research Projects Coordination Unit with project number TTU-2021-9631.
The data that support the findings of this study are available from the corresponding author upon reasonable request.