Haydar Kaplan1, Demet Yalcin Kehribar2, Muhammed Okuyucu2, Metin Ozgen3

1Department of Internal Medicine, Suluova State Hospital, Amasya, Türkiye
2Department of Internal Medicine, Ondokuz Mayıs University Faculty of Medicine, Samsun, Türkiye
3Department of Internal Medicine, Division of Rheumatology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Türkiye

Keywords: Behçet’s disease, inflammation, tenascin-C.


Objectives: The study aimed to investigate serum tenascin-C levels and its relationship with pathogenesis of Behçet’s disease (BD) with inflammatory processes.

Patients and methods: This prospective and analytical study included 34 BD patients (19 males, 15 females; mean age: 31.5±8.2 years; range, 18 to 48 years) who met the 2014 International Criteria for Behçet's Disease and had no comorbidities and 37 healthy volunteers (21 females, 16 males; mean age: 29.6±5.3 years; range, 21 to 45 years). Sex, age, age at diagnosis, clinical and laboratory data, medication use, and smoking history of the participants were recorded. Serum tenascin-C levels were measured using a commercially available tenascin-C enzyme-linked immunosorbent assay kit.

Results: There was no significant difference between the groups in terms of age (p=0.262) and sex (p=0.287). Serum tenascin-C levels were significantly lower in the BD group (10,824±7,612 pg/mL) compared to the control group (27,574±14,533 pg/mL, p<0.001). In the receiver operating characteristic analysis performed for the diagnostic value of tenascin-C level in BD, the sensitivity was determined as 79.4% and the specificity as 82.5% (p<0.001). No statistically significant difference was observed in tenascin-C levels in correlation with clinical characteristics, laboratory values, medication use, and smoking in the BD group.

Conclusion: In contrast to other chronic inflammatory diseases, lower levels of tenascin-C were observed in patients with BD than in the healthy individuals, which can be attributed to the absence of prolonged chronic inflammatory course in BD. The fact that tenascin-C levels are high in other rheumatic inflammatory diseases but low in BD may be useful in the differential diagnosis of BD.

Citation: Kaplan H, Yalcin Kehribar D, Okuyucu M, Ozgen M. An investigation of the relationship between Behçet’s disease and tenascin-C. Arch Rheumatol 2024;39(1):107-114. doi: 10.46497/ ArchRheumatol.2024.10163.

Ethics Committee Approval

The study protocol was approved by the Ondokuz Mayıs University Clinical Research Ethics Committee (date: 27.10.2021, no: B.30.2.ODM.0.20.08/646-423). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Author Contributions

Idea/concept: H.K.; Design: D.Y.K., M.O; Control/supervision: M.O.; Data Collection and/or processing: H.K.; Analysis and/or interpretation: D.Y.K.; Literature review: M.O.; Writing the article: H.K., D.Y.K.; Critical review: M.O.; References and fundings: M.O.; Materials: D.Y.K.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.