Serdar Kaymaz1, Nilüfer Savurmuş2, Uğur Karasu1, Hüseyin Kaya3, Furkan Ufuk4, Ayşe Rüksan Ütebey4, Veli Çobankara1, Murat Yiğit1

1Department of Internal Medicine, Division of Rheumatology, Pamukkale University Faculty of Medicine, Denizli, Türkiye
2Department of Chest Disease and Pulmonology, Pamukkale University Faculty of Medicine, Denizli, Türkiye
3Department of Opthalmology, Pamukkale University Faculty of Medicine, Denizli, Türkiye
4Department of Radiology, Pamukkale University Faculty of Medicine, Denizli, Türkiye

Keywords: Choroidal thickness, rheumatoid arthritis, ΔHRCT.


Objectives: This study aimed to evaluate choroidal thickness (CT) in patients with rheumatoid arthritis (RA) and healthy controls and to determine its relationship with RA-associated interstitial lung disease (RA-ILD).

Patients and methods: A total of 63 patients with RA and 36 age- and sex-matched healthy controls were recruited in the cross-sectional study. Serological findings, Disease Activity Score-28, disease duration, and medical treatment of patients were recorded. Patients with RA were subdivided into two groups: patients with RA-ILD (Group 1) and patients with RA but without ILD (RA-noILD; Group 2). CTs were measured using enhanced depth imaging optical coherence tomography. CT was measured at five points: the subfoveal region, 750 μm nasal and temporal to the fovea, 1500 μm nasal and temporal to the fovea. Patients with RA-ILD were evaluated with delta high-resolution computed tomography (ΔHRCT) and pulmonary function test to determine the severity of interstitial lung disease.

Results: Four of 63 RA patients were excluded due to comorbidities. Thus, 59 RA patients, 20 in the RA-ILD group and 39 in the RA-noILD group, were included in the analyses. The RA groups were similar in terms of clinical characteristics and laboratory findings. There were statistically significant differences between Group 1, Group 2 and healthy controls (Group 3) compared to all CT values (p<0.05). The mean CT measured at 750 μm and 1500 μm nasal to the fovea was lowest in the RA-ILD group, followed by the RA-noILD and healthy groups (p<0.05). CT measurements did not correlate with the pulmonary function test and ΔHRCT.

Conclusion: RA-ILD patients had a thinner CT measured at nasal points. However, there was no association between CT measurements and the severity of ILD.

Citation: Kaymaz S, Savurmuş N, Karasu U, Kaya H, Ufuk F, Rüksan Ütebey A, et al. Association between choroidal thickness and interstitial lung disease in patients with rheumatoid arthritis: A cross-sectional study. Arch Rheumatol 2024;39(1):89-98. doi: 10.46497/ ArchRheumatol.2024.10116.

Ethics Committee Approval

The study protocol was approved by the Pamukkale University Faculty of Medicine Ethics Committee (date: 15.06.21, no: 60116787-020-110161). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Author Contributions

Idea/concept: K.S., S.N.; Design: K.S.; Control/supervision: K.S., U.F., K.H.; Data collection and/or processing: K.S., C.V., U.F.; Analysis and/or interpretation: K.S., S.N., Y.M.; Literature review: K.S.; Writing the article: K.S., U.F., S.N., U.R.A.; Critical review: K.S., K.H., C.V.; References and fundings: K.S., Y.M., U.R.A.; Materials: K.S., S.N., K.U., K.H., C.V.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.