The relationship between Mycoplasma and Kawasaki disease in pediatric patients: An updated systematic review and meta-analysis
Min Cheng1
, Gaihuan Zheng2, Lu Gao1, Bihong Zhang3
1Department of Pediatrics, Chongqing Medical University, Chongqing, China
2Department of Infectious Diseases, Children's Hospital of Chongqing Medical University, Chongqing, China
3Department of Psychology, Central China Normal University, Wuhan, China
Keywords: Erythrocyte sedimentation rate, hemoglobin, Kawasaki disease, meta-analysis, mycoplasma, pooled prevalence.
Abstract
Objectives: This study aimed to clarify the relationship between Mycoplasma pneumoniae (M. pneumoniae) and Kawasaki disease by conducting an updated systemic review and meta-analysis of published studies.
Materials and methods: Studies mentioning M. pneumoniae and Kawasaki disease before October 2022 were included in this meta-analysis. The pooled prevalence was calculated, and the log odds ratio in the random effects model was applied to estimate the pooled prevalence of M. pneumoniae infection in pediatric patients with Kawasaki disease. In addition, the clinical parameters, such as hemoglobin and erythrocyte sedimentation rate, were analyzed. Six studies with a total of 1,859 pediatric patients with Kawasaki disease were enrolled. The focused outcome was the pooled prevalence and clinical parameters.
Results: The pooled prevalence of M. pneumoniae infection was statistically significant in pediatric patients with Kawasaki disease. In addition, the values of hemoglobin and erythrocyte sedimentation rate were significantly different between M. pneumoniae-infected and non-M. pneumoniae-infected patients with Kawasaki disease. Other clinical parameters were not significantly different between M. pneumoniae-infected and non-M. pneumoniae-infected patients with Kawasaki disease.
Conclusion: The results suggest that M. pneumoniae infection is significantly prevalent in pediatric patients with Kawasaki disease. The lower values of hemoglobin and erythrocyte sedimentation rate in M. pneumoniae-infected patients with Kawasaki disease might be needed to investigate further.
Citation: Cheng M, Zheng G, Gao L, Zhang B. The relationship between Mycoplasma and Kawasaki disease in pediatric patients: An updated systematic review and meta-analysis. Arch Rheumatol 2024;39(1):140-148. doi: 10.46497/ ArchRheumatol.2024.10149.
Research idea and study design: ZG and CM; data acquisition: Z.G., C.M.; Data analysis/interpretation: Z.G., C.M.; Statistical analysis: G.L., Z.B.; Supervision or mentorship: Z.B.; All authors takes responsibility that this study has been reported honestly, accurately and transparently, and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or integrity of any portion of the work are appropriately investigated and resolved.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
The data that support the findings of this study are available from the corresponding author upon reasonable request.