Clinical study of factors associated with pregnancy outcomes in pregnant women with systemic lupus erythematosus in the southern China
Ke Zhang1
, Chunmei He1, Qiaoting Deng2,3, Wengen Li1, Zhixiong Zhong2,3, Jingyuan Hou2,3
1Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
2Department of Research Experimental Center, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
3Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, P. R. China
Keywords: Adverse pregnancy outcomes, preeclampsia, systemic lupus erythematosus.
Abstract
Objectives: This study aims to estimate predicted factors for maternal and fetal outcomes in Hakka pregnant women with systemic lupus erythematosus (SLE) in the southern China.
Patients and methods: Between June 2014 and February 2020, we retrospectively analyzed the data of a total of 123 singleton pregnant women with SLE (mean age: 27.1±4.1 years; range, 19 to 39 years) who were referred to our rheumatology clinic. Demographic, clinical, and laboratory data of the patients were recorded. Adverse pregnancy outcomes (APOs) were assessed.
Results: Multivariate logistic regression analysis revealed that preeclampsia was associated with the increased odds of APOs (odds ratios [OR]=9.538, 95% confidence interval [CI]: 2.055-44.271, p=0.004), premature birth (OR=14.289, 95% CI: 3.596-56.777, p<0.001) and low birth weight (OR=8.275, 95% CI: 2.117-32.345, p=0.002). Anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibody positivity was the predictor of APOs (OR=2.165, 95% CI: 1.034-4.532, p=0.040), premature birth (OR=2.849, 95% CI: 1.220-6.657, p=0.016) and pregnancy loss (OR=3.004, 95% CI: 1.086-8.305, p=0.034). The use of hydroxychloroquine and prednisone was associated with the decreased odds of APOs (OR=0.412, 95% CI: 0.198-0.860, p=0.018) and pregnancy loss (OR=0.304, 95% CI: 0.111-0.831, p=0.020).
Conclusion: Our study results indicate that preeclampsia, anti-dsDNA antibody positivity, and the use of hydroxychloroquine and prednisone are independent predictors of pregnancy outcomes.
Citation: Zhang K, He C, Deng Q, Li W, Zhong Z, Hou J. Clinical study of factors associated with pregnancy outcomes in pregnant women with systemic lupus erythematosus in the southern China. Arch Rheumatol 2022;37(1):59-66.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
This study was supported by Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translation Research of Hakka Population Grants [2018B030322003], and Science and Technology Program of Meizhou Grants [2018B007].