Hatice BODUR1, Fatma GÜL YURDAKUL1, Mehmet Tuncay DURUÖZ2, Hasan Fatih ÇAY3, Ülkü UÇAR3, Yaşar KESKİN4, Betül SARGIN5, Gülcan GÜRER5, Ozan Volkan YURDAKUL4, Mustafa ÇALIŞ6, Hülya DEVECİ7, Yıldıray AYDIN8, Sami HİZMETLİ9, Remzi ÇEVİK10, Ali Yavuz KARAHAN11, Şebnem ATAMAN12, Hilal ECESOY13, Zafer GÜNENDİ14, Murat TOPRAK15, Nesrin ŞEN16, Duygu ALTINTAŞ17, Ahmet Kıvanç CENGİZ18, Gökhan ÇAĞLAYAN9, Ali Nail DEMİR19, Hüseyin Kaplan6, Sertaç KETENCİ20, Meltem Alkan MELİKOĞLU17, Mehmet NAYİMOĞLU21, Kemal NAS8, Banu SARIFAKIOĞLU21, İlhan SEZER19

1Department of Physical Medicine and Rehabilitation, Ankara City Hospital, Ankara, Turkey
2Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey
3Rheumatology, Antalya Training and Research Hospital, Antalya, Turkey
4Department of Physical Medicine and Rehabilitation, Bezmialem Vakıf University Faculty of Medicine, Istanbul, Turkey
5Rheumatology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey
6Department of Physical Medicine and Rehabilitation, Erciyes University Faculty of Medicine, Kayseri, Turkey
7Department of Physical Medicine and Rehabilitation, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey
8Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
9Rheumatology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
10Department of Physical Medicine and Rehabilitation, Dicle University Faculty of Medicine, Diyarbakır, Turkey
11Department of Physical Medicine and Rehabilitation, Uşak University Faculty of Medicine, Uşak, Turkey
12Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey
13Rheumatology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey
14Department of Physical Medicine and Rehabilitation, Gazi University Faculty of Medicine, Ankara, Turkey
15Department of Physical Medicine and Rehabilitation, Van Yüzüncü Yıl University Faculty of Medicine, Van, Turkey
16Rheumatology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey
17Rheumatology, Atatürk University Faculty of Medicine, Erzurum, Turkey
18Rheumatology, Sivas Numune Training and Research Hospital, Sivas, Turkey
19Rheumatology, Akdeniz University Faculty of Medicine, Antalya, Turkey
20Rheumatology, Giresun University Faculty of Medicine, Giresun, Turkey
21Department of Physical Medicine and Rehabilitation, Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey

Keywords: Autoinflammatory diseases, depression, fatigue, hereditary, life quality

Abstract

Objectives: This study aims to evaluate the effectivity of Familial Mediterranean Fever Quality of Life (FMF-QoL) Scale for the measurement of QoL in patients with FMF and to perform correlations between related clinical variables in Turkish patients.

Patients and methods: This multicenter prospective study performed between December 2017 and November 2018 included 974 FMF patients (334 males, 640 females; median age 35; range, 26 to 45 years). Sociodemographic characteristics and clinical features were recorded. All participants were asked to complete the FMF-QoL Scale, Short Form-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), Health Assessment Questionnaire (HAQ), and Functional Assessment of Chronic Illness Therapy (FACIT) Scale.

Results: The median FMF-QoL Scale score was 26. Higher FMF-QoL Scale scores were shown to be related to female sex, illiteracy or primary education, monthly low-income (US$<300), smoking, late-onset FMF (>20 years), a higher number of attacks per month (>1/month), and severe disease. FMF-QoL Scale scores were correlated negatively with subscales of SF-36, and positively with HADS-anxiety and HADS-depression scores, HAQ and FACIT.

Conclusion: Female sex, smoking, lower educational status, more severe disease, fatigue, and functional impairment were associated with poor QoL. FMF-QoL Scale was noted as a valid and simple patient-reported outcome instrument and correlated with the SF-36 scale.

Citation: Bodur H, Yurdakul FG, Duruöz MT, Çay HF, Uçar Ü, Keskin Y. Familial Mediterranean Fever: Health-Related Quality of Life and Associated Variables in a National Cohort. Arch Rheumatol 2021;36(x):i-viii.