Published In
Archives of Rheumatology
Volume 32 · Issue 1
Pages: 010-014
History
Published Online: March 31, 2017
This work is licensed under a Creative Commons Attribution 4.0 International License.
Nilüfer GALİP
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Ceyhun DALKAN
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Ayşe TERALI
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Nazan ÇOBANOĞLU
Department of Pediatrics, Division of Pediatric Pulmonology, Medical Faculty of Ankara University, Ankara, Turkey
Ayfer ÜLGENALP
Department of Medical Genetics, Medical Faculty of Dokuz Eylül University, İzmir, Turkey
Nerin BAHÇECİLER
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Salih KAVUKÇU
Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology, Medical Faculty of Dokuz Eylül University, İzmir, Turkey
Nilüfer GALİP, Ceyhun DALKAN, Ayşe TERALI, Nazan ÇOBANOĞLU, Ayfer ÜLGENALP, Nerin BAHÇECİLER, & Salih KAVUKÇU. (2017). Prevalence of Mediterranean FeVer Gene Mutations in Turkish Cypriot Population. Archives of Rheumatology, 32(1), 010–014. https://doi.org/10.5606/ArchRheumatol.2017.5791
Abstract
Objectives: This study aims to determine the carrier frequency and the most common mutations of the Mediterranean FeVer (MEFV) gene in healthy Cypriot population of Turkish origin.
Patients and methods: A total of 296 healthy participants (102 males, 194 females; median age 30 years; range 1 to 81 years) were evaluated. The exon 2, 3, 5 and 10 of MEFV genes were amplified by polymerase chain reaction.
Results: The participants demonstrated an extremely high carrier rate (12.5%). Most commonly detected mutations were E148Q and A74S, with rates of 7.3% and 2.8%, respectively.
Conclusion: Mediterranean FeVer gene mutation types and carrier rates in Turkish Cypriot population are different than other Mediterranean populations in the region. MEFV mutation carriage is frequent in North Cyprus and familial Mediterranean fever might be one of the causes for end stage renal disease in Turkish Cypriots.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Volume 32 · Issue 1
Pages
010-014
History
Published Online
March 31, 2017
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
Nilüfer GALİP
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Ceyhun DALKAN
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Ayşe TERALI
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Nazan ÇOBANOĞLU
Department of Pediatrics, Division of Pediatric Pulmonology, Medical Faculty of Ankara University, Ankara, Turkey
Ayfer ÜLGENALP
Department of Medical Genetics, Medical Faculty of Dokuz Eylül University, İzmir, Turkey
Nerin BAHÇECİLER
Department of Pediatrics, Near East University Faculty of Medicine, Lefkoşa, Turkish Republic of Northern Cyprus
Salih KAVUKÇU
Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology, Medical Faculty of Dokuz Eylül University, İzmir, Turkey
Cite this Article
Nilüfer GALİP, Ceyhun DALKAN, Ayşe TERALI, Nazan ÇOBANOĞLU, Ayfer ÜLGENALP, Nerin BAHÇECİLER, & Salih KAVUKÇU. (2017). Prevalence of Mediterranean FeVer Gene Mutations in Turkish Cypriot Population. Archives of Rheumatology, 32(1), 010–014. https://doi.org/10.5606/ArchRheumatol.2017.5791
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