Published In
Archives of Rheumatology
Volume: 32 Issue: 1, March 2017
Pages: 003-009
History
Published Online: March 31, 2017
This work is licensed under a Creative Commons Attribution 4.0 International License.
Saliha Handan YILDIZ
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Alper Murat ULAŞLI
Department of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Müjgan ÖZDEMİR ERDOĞAN
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Ömer DİKİCİ
Department of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Evrim Suna ARIKAN TERZİ
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Ümit DÜNDAR
Department of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Mustafa SOLAK
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Saliha Handan YILDIZ, Alper Murat ULAŞLI, Müjgan ÖZDEMİR ERDOĞAN, Ömer DİKİCİ, Evrim Suna ARIKAN TERZİ, Ümit DÜNDAR, & Mustafa SOLAK. (2017). Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism. Archives of Rheumatology, 32(1), 003–009. https://doi.org/10.5606/ArchRheumatol.2017.5846
Abstract
Objectives: This study aims to investigate the association of two common HTR2A gene polymorphisms, rs6313 (102 T/C) and rs6311 (1438 A/G), with chronic low back pain (CLBP) and the pain threshold, disability, and sex differences.
Patients and methods: A total of 121 patients (40 males, 81 females; mean age 36.8±9.9 years; range 18 to 50 years) having CLBP and 91 healthy controls (26 males, 65 females; mean age 34.1±10.2 years; range 18 to 55 years) were included. Pressure pain thresholds (PPTs) of all participants were examined with manual algometer in certain sites of their body.
Results: The PPTs were all decreased in CLBP patients (p<0.05). Although PPTs were lower in healthy female subjects, there was no sex difference regarding PPTs in CLBP patients (p>0.05). rs6311 polymorphism of HTR2A gene was associated with CLBP (p<0.05). In rs6313 polymorphism, at least one copy of T carriers and in rs6311 polymorphism, at least one copy of G carriers showed higher disability.
Conclusion: The PPT decreases in CLBP patients similar to other chronic pain conditions without any sex difference. Although rs6311 single nucleotide polymorphism of HTR2A gene was associated with CLBP and rs6313 polymorphism was not, rs6311 might have a protective effect on disability of these patients.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Vol. 32 No. 1 (2017): The Archives of Rheumatology
Pages
003-009
History
Published Online
March 31, 2017
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
1
Saliha Handan YILDIZ
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
2
Alper Murat ULAŞLI
Department of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
3
Müjgan ÖZDEMİR ERDOĞAN
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
4
Ömer DİKİCİ
Department of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
5
Evrim Suna ARIKAN TERZİ
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
6
Ümit DÜNDAR
Department of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
7
Mustafa SOLAK
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey
Cite this Article
Saliha Handan YILDIZ, Alper Murat ULAŞLI, Müjgan ÖZDEMİR ERDOĞAN, Ömer DİKİCİ, Evrim Suna ARIKAN TERZİ, Ümit DÜNDAR, & Mustafa SOLAK. (2017). Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism. Archives of Rheumatology, 32(1), 003–009. https://doi.org/10.5606/ArchRheumatol.2017.5846
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