Published In
Archives of Rheumatology
Volume: 31 Issue: 3, September 2016
Pages: 229-233
History
Published Online: September 30, 2016
This work is licensed under a Creative Commons Attribution 4.0 International License.
Orhan KÜÇÜKŞAHİN
Division of Rheumatology, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey
Mustafa Turgut YILDIZGÖREN
Department of Physical Medicine and Rehabilitation, Medical Faculty of Mustafa Kemal University, Hatay, Turkey
Demet Menekşe GEREDE
Department of Cardiology, Medical Faculty of Ankara University, Ankara, Turkey
Yüksel MARAŞ
Division of Rheumatology, Atatürk Training and Research Hospital, Ankara, Turkey
Şükran ERTEN
Division of Rheumatology, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey
Orhan KÜÇÜKŞAHİN, Mustafa Turgut YILDIZGÖREN, Demet Menekşe GEREDE, Yüksel MARAŞ, & Şükran ERTEN. (2016). Bosentan For Digital Ulcers in Patients With Systemic Sclerosis: Single Center Experience. Archives of Rheumatology, 31(3), 229–233. https://doi.org/10.5606/ArchRheumatol.2016.5811
Abstract
Objectives: This study aims to investigate the effects of bosentan on the prevention and treatment of digital ulcers in systemic sclerosis (SSc) patients.
Patients and methods: The study included 30 patients (4 males, 26 females; mean age 49.6±15.4 years; range 23 to 71 years) diagnosed with SSc and treated with bosentan for digital ulcers. Bosentan was administered to all patients for a mean of 14±10.3 months. All SSc cases were refractory to calcium channel antagonists or angiotensin II inhibitors. The diagnosis of SSc was based on the American College of Rheumatology criteria and patients were classified as limited or diffuse cutaneous SSc according to the LeRoy classification.
Results: Mean disease duration was 8.8±8.0 years and mean duration of digital ulcers was 29.4±6.6 months. Under the bosentan treatment, eight patients (26.7%) developed new digital ulcers; all of these patients had diffuse cutaneous SSc. Health Assessment Questionnaire scores improved after 12 months and 24 months of treatment (p<0.001). Three patients (10%) developed pulmonary arterial hypertension under bosentan treatment [two patients (6.6%) had SSc-associated pulmonary arterial hypertension and one patient (3.3%) had interstitial fibrosis-associated pulmonary arterial hypertension]. The anti-centromere antibody positive patients were predominantly classified as limited cutaneous SSc. Of the patients positive for anti-topoisomerase-1 antibodies, a high proportion was classified as diffuse cutaneous SSc. Pulmonary fibrosis was most frequent in the anti-topoisomerase-1 antibody subset. New digital ulcers developed mainly in the anti-topoisomerase-1 antibody positive patients.
Conclusion: Bosentan may be used either alone or in combination with other treatments when digital ulcers worsen and may be expected to suppress the development of new ulcers and severe pain. Further preclinical studies are required shedding light on the etiopathogenesis of SSc and larger clinical trials are needed for more definitive treatment strategies.
Similar Articles
Similar Articles
- Irem Sahinoğlu, Ozgül Soysal Gündüz, Secil Sari, Müge Gencer Tuluy, Emre Ali Acar, Seref Sülükcü, Filiz Cemre Tasgöz, Mevlüt Kacar, Sadettin Uslu, Deniz Kizilirmak, Timur Pirildar, Association of Health-Related Quality of Life with Functional and Radiological Outcomes in Patients with Rheumatoid Arthritis–Associated Interstitial Lung Disease, Systemic Sclerosis–Associated Interstitial Lung Disease, and Idiopathic Pulmonary Fibrosis , Archives of Rheumatology: Vol. 40 No. 3 (2025): Archives of Rheumatology
- Luis Javier Cajas Santana, Satiago Cuero, Gabriela Guerrero, Mayelin Ceballos, María Carolina Torres Villarreal, Correlation of Pleural and Pulmonary Ultrasound with the Severity of Autoimmune Interstitial Lung Disease , Archives of Rheumatology: Vol. 40 No. 3 (2025): Archives of Rheumatology
- Wenyu Xu, Peiying Nie, Qian Li, Bingjie Gu, Qijie Ren, Xingguo Chen, Exosomal microRNAs in Different Disease Activity Status in Systemic Lupus Erythematosus: A Retrospective Study , Archives of Rheumatology: Vol. 40 No. 3 (2025): Archives of Rheumatology
- Nilay Şahin, Ender Salbaş, The Gut-Joint Connection: Microbiome’s Role in Rheumatic Disease , Archives of Rheumatology: Vol. 40 No. 4 (2025): Archives of Rheumatology
- Su Jin Choi, Min Wook So, Kyung Don Yoo, Sunggun Lee, Seung Won Choi, Doo-Ho Lim, Association Between Time–Averaged Serum Uric Acid Level and Subsequent Renal Involvement in Premenopausal Patients with Systemic Lupus Erythematosus , Archives of Rheumatology: Vol. 40 No. 4 (2025): Archives of Rheumatology
- Branislav Slenker, Peter Banovcin, Katarina Hrubiskova, Veronika Vargova, Anna Bobcakova, Dusana Gensor, Eva Malicherova Jurkova, Daniela Kapustova, Lenka Kapustova, Adam Markocsy, Otilia Petrovicova, Milos Jesenak, TNF Receptor–Associated Periodic Syndrome: An Analysis of a Slovakian Cohort of TRAPS Patients , Archives of Rheumatology: Vol. 40 No. 3 (2025): Archives of Rheumatology
- Serap Diktaş Tahtasakal, Coşkun Doğan, Thoracic Ultrasound in Assessment of the Pleura in Connective Tissue Disease , Archives of Rheumatology: Vol. 40 No. 4 (2025): Archives of Rheumatology
- Adem KÜÇÜK, Sinan BAĞCACI, Yalçın SOLAK, Recep TUNÇ1, Digital Ulcer as a Rare Complication of Systemic Lupus Erythematosus: A Case Report , Archives of Rheumatology: Vol. 29 No. 1 (2014): The Archives of Rheumatology
- Adrian Lee, Fibrillarin antibodies in systemic sclerosis , Archives of Rheumatology: Vol. 37 No. 2 (2022): The Archives of Rheumatology
- Jucier Gonçalves Júnior, Percival Degrava Sampaio-Barros, Takashi Matsushita, Yasuhito Hamaguchi, Fujiko Someya, João Calvino Soares De Oliveira, Fernando Henrique Carlos De Souza, Renata Miossi, Pleiades Tiharu Inaoka, Naoki Mugii, Samuel Katsuyuki Shinjo, Patients with inflammatory myopathies overlapping with systemic sclerosis: A Brazilian-Japanese bicentric study , Archives of Rheumatology: Vol. 38 No. 1 (2023): The Archives of Rheumatology
You may also start an advanced similarity search for this article.
Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Vol. 31 No. 3 (2016): The Archives of Rheumatology
Pages
229-233
History
Published Online
September 30, 2016
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
1
Orhan KÜÇÜKŞAHİN
Division of Rheumatology, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey
2
Mustafa Turgut YILDIZGÖREN
Department of Physical Medicine and Rehabilitation, Medical Faculty of Mustafa Kemal University, Hatay, Turkey
3
Demet Menekşe GEREDE
Department of Cardiology, Medical Faculty of Ankara University, Ankara, Turkey
4
Yüksel MARAŞ
Division of Rheumatology, Atatürk Training and Research Hospital, Ankara, Turkey
5
Şükran ERTEN
Division of Rheumatology, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey
Cite this Article
Orhan KÜÇÜKŞAHİN, Mustafa Turgut YILDIZGÖREN, Demet Menekşe GEREDE, Yüksel MARAŞ, & Şükran ERTEN. (2016). Bosentan For Digital Ulcers in Patients With Systemic Sclerosis: Single Center Experience. Archives of Rheumatology, 31(3), 229–233. https://doi.org/10.5606/ArchRheumatol.2016.5811
Outlines