Published In
Archives of Rheumatology
Volume: 17 Issue: 2, June 2002
Pages: 112-117
History
Published Online: June 30, 2002
This work is licensed under a Creative Commons Attribution 4.0 International License.
Şirzat Çoğalgil
Atatürk Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı
Orhan Karsan
Atatürk Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı
Lale Cerrahoğlu
Celal Bayar Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı Başkanı
Mahir Uğur
Atatürk Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı
Halis Süleyman
Atatürk Üniversitesi Tıp Fakültesi Farmakoloji Anabilim Dalı
Cemal Gündoğdu
Atatürk Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı
Fazlı Erdoğan
Atatürk Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı
Şirzat Çoğalgil, Orhan Karsan, Lale Cerrahoğlu, Mahir Uğur, Halis Süleyman, Cemal Gündoğdu, & Fazlı Erdoğan. (2002). EFFECTS OF INTRAARTICULAR HYALURONIC ACID AND METHYL PREDNISOLONE ACETATE ON CARTILAGE IN A MODEL OF EXPERIMENTAL ARTHRITIS IN RATS. Archives of Rheumatology, 17(2), 112–117. Retrieved from https://archivesofrheumatology.org/index.php/pub/article/view/79
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Abstract
This experimental study was performed to determine the effects of intraarticular hyaluronic acid (HA) and methyl prednisolone acetate (MPA) in degenerative osteoarthritis. 0.2 ml 1% formaline were injected to the posterior right knee joints of 40 male rats. One week after the injections, 10 rats were killed and arthritis was determined histopathologically. The remained 30 rats were divided to three groups. First group received intraarticularly 0.05 ml HA (HA group), second group 0.05 ml MPA (MPA group) and third group 0.05 ml saline as controls. The injections were performed at 7., 14. and 21. days after the arthritis. 15 days after the end of these treatments, rats were killed and sections were examined histopathologically.
There was no significantly difference in cartilage healing between MPA and control groups (p>0.05). However cartilage healing was significantly high in HA group compared to MPA and control groups (p<0.05).
It was concluded that HA is more useful than MPA in the treatment of arthritis intraarticularly because of its positive effects on cartilage tissue.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Vol. 17 No. 2 (2002): The Archives of Rheumatology
Pages
112-117
History
Published Online
June 30, 2002
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
1
Şirzat Çoğalgil
Atatürk Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı
2
Orhan Karsan
Atatürk Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı
3
Lale Cerrahoğlu
Celal Bayar Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı Başkanı
4
Mahir Uğur
Atatürk Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı
5
Halis Süleyman
Atatürk Üniversitesi Tıp Fakültesi Farmakoloji Anabilim Dalı
6
Cemal Gündoğdu
Atatürk Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı
7
Fazlı Erdoğan
Atatürk Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı
Cite this Article
Şirzat Çoğalgil, Orhan Karsan, Lale Cerrahoğlu, Mahir Uğur, Halis Süleyman, Cemal Gündoğdu, & Fazlı Erdoğan. (2002). EFFECTS OF INTRAARTICULAR HYALURONIC ACID AND METHYL PREDNISOLONE ACETATE ON CARTILAGE IN A MODEL OF EXPERIMENTAL ARTHRITIS IN RATS. Archives of Rheumatology, 17(2), 112–117. Retrieved from https://archivesofrheumatology.org/index.php/pub/article/view/79
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