Published In
Archives of Rheumatology
Volume 40 · Issue 2
Pages: 189-196
History
Published Online: June 30, 2025
This work is licensed under a Creative Commons Attribution 4.0 International License.
Sooin Park
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Moon-Ju Kim
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Yu Jeong Lee
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Sung Min Yu
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Hae-in Lee
Division of Biodurg Evaluation, NDDC, Osong Medical Innovation Foundation (KBIOHealth), Cheongju, Republic of Korea
So-Hee Jin
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
A-ra Choi
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Seung Cheol Shim
Division of Rheumatology, Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Republic of Korea
Eun Jeong Won
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Tae-Jong Kim
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Park, S., Kim, M.-J., Lee, Y. J., Yu, S. M., Lee, H.- in, Jin, S.-H., … Kim, T.-J. (2025). A Pilot Study on the Anti-Inflammatory Effects of Tacrolimus in Ankylosing Spondylitis: Evidence from Human Samples and a Murine Model. Archives of Rheumatology, 40(2), 189–196. https://doi.org/10.5152/ArchRheumatol.2025.11154
Abstract
Background/Aims: Evaluate anti-inflammatory and therapeutic effects of tacrolimus in ankylosing spondylitis (AS).
Materials and Methods: PBMCs and SFMCs from AS patients treated with tacrolimus; flow cytometry measured IFN-γ, IL-17A, GM-CSF. Cytokines (IFN-γ, IL-17A, TNF-α, GM-CSF) in PBMC supernatants by ELISA. In vivo AS mouse model: clinical arthritis scores and flow cytometry for IFN-γ, IL-17A, TNF-α.
Results: Tacrolimus suppressed cytokine production in patient PBMCs/SFMCs. In mice, tacrolimus reduced arthritis scores and cytokine-producing cells.
Conclusion: Tacrolimus shows potential as AS therapy by suppressing inflammatory cytokines ex vivo and in vivo models.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Volume 40 · Issue 2
Pages
189-196
History
Published Online
June 30, 2025
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
Sooin Park
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Moon-Ju Kim
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Yu Jeong Lee
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Sung Min Yu
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Hae-in Lee
Division of Biodurg Evaluation, NDDC, Osong Medical Innovation Foundation (KBIOHealth), Cheongju, Republic of Korea
So-Hee Jin
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
A-ra Choi
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Seung Cheol Shim
Division of Rheumatology, Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Republic of Korea
Eun Jeong Won
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Tae-Jong Kim
Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea
Cite this Article
Park, S., Kim, M.-J., Lee, Y. J., Yu, S. M., Lee, H.- in, Jin, S.-H., … Kim, T.-J. (2025). A Pilot Study on the Anti-Inflammatory Effects of Tacrolimus in Ankylosing Spondylitis: Evidence from Human Samples and a Murine Model. Archives of Rheumatology, 40(2), 189–196. https://doi.org/10.5152/ArchRheumatol.2025.11154
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