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Published In
Archives of Rheumatology
Volume: 37 Issue: 1, March 2022
Pages: 059-066
History
Published Online: March 31, 2022
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ke Zhang
Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
Chunmei He
Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
Qiaoting Deng
Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, P. R. China
Wengen Li
Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
Zhixiong Zhong
Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, P. R. China
Jingyuan Hou
Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, P. R. China
Ke Zhang, Chunmei He, Qiaoting Deng, Wengen Li, Zhixiong Zhong, & Jingyuan Hou. (2022). Clinical study of factors associated with pregnancy outcomes in pregnant women with systemic lupus erythematosus in the southern China. Archives of Rheumatology, 37(1), 059–066. https://doi.org/10.46497/ArchRheumatol.2022.8870
Abstract
Objectives: This study aims to estimate predicted factors for maternal and fetal outcomes in Hakka pregnant women with systemic lupus erythematosus (SLE) in the southern China.
Patients and methods: Between June 2014 and February 2020, we retrospectively analyzed the data of a total of 123 singleton pregnant women with SLE (mean age: 27.1±4.1 years; range, 19 to 39 years) who were referred to our rheumatology clinic. Demographic, clinical, and laboratory data of the patients were recorded. Adverse pregnancy outcomes (APOs) were assessed.
Results: Multivariate logistic regression analysis revealed that preeclampsia was associated with the increased odds of APOs (odds ratios [OR]=9.538, 95% confidence interval [CI]: 2.055-44.271, p=0.004), premature birth (OR=14.289, 95% CI: 3.596-56.777, p<0.001) and low birth weight (OR=8.275, 95% CI: 2.117-32.345, p=0.002). Anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibody positivity was the predictor of APOs (OR=2.165, 95% CI: 1.034-4.532, p=0.040), premature birth (OR=2.849, 95% CI: 1.220-6.657, p=0.016) and pregnancy loss (OR=3.004, 95% CI: 1.086-8.305, p=0.034). The use of hydroxychloroquine and prednisone was associated with the decreased odds of APOs (OR=0.412, 95% CI: 0.198-0.860, p=0.018) and pregnancy loss (OR=0.304, 95% CI: 0.111-0.831, p=0.020).
Conclusion: Our study results indicate that preeclampsia, anti-dsDNA antibody positivity, and the use of hydroxychloroquine and prednisone are independent predictors of pregnancy outcomes.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Vol. 37 No. 1 (2022): The Archives of Rheumatology
Pages
059-066
History
Published Online
March 31, 2022
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
1
Ke Zhang
Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
2
Chunmei He
Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
3
Qiaoting Deng
Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, P. R. China
4
Wengen Li
Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China
5
Zhixiong Zhong
Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, P. R. China
6
Jingyuan Hou
Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, P. R. China
Cite this Article
Ke Zhang, Chunmei He, Qiaoting Deng, Wengen Li, Zhixiong Zhong, & Jingyuan Hou. (2022). Clinical study of factors associated with pregnancy outcomes in pregnant women with systemic lupus erythematosus in the southern China. Archives of Rheumatology, 37(1), 059–066. https://doi.org/10.46497/ArchRheumatol.2022.8870
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