Published In
Archives of Rheumatology
Volume: 35 Issue: 1, March 2020
Pages: 052-059
History
Published Online: March 31, 2020
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ferhat DEMİR
Department of Pediatric Rheumatology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
Alper Han ÇEBİ
Department of Medical Genetics, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
Mukaddes KALYONCU
Department of Pediatric Rheumatology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
Ferhat DEMİR, Alper Han ÇEBİ, & Mukaddes KALYONCU. (2020). Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. Archives of Rheumatology, 35(1), 052–059. https://doi.org/10.5606/ArchRheumatol.2020.7414
Abstract
Objectives: This study aims to evaluate the plasma expression of microribonucleic acids (miRNAs) that may be associated with the pathogenesis of familial Mediterranean fever (FMF).
Patients and methods: Thirty patients with FMF (18 males, 12 females; mean age 9.1±4.7 years; range, 3 to 15.5 years) and 30 age- and sex-matched healthy children (18 males, 12 females; mean age 9.5±4.6 years; range, 4 to 16.5 years) were included in this study. The plasma levels of four candidate miRNAs (miRNA-16, miRNA-155, miRNA-204 and miRNA-451) were measured in all subjects. The plasma levels of miRNAs were analyzed with real- time polymerase chain reaction in attack and remission periods of patients and healthy controls (HCs).
Results: Plasma miRNA-204 levels of FMF patients were decreased 6.5 fold in remission period compared to HCs (p<0.001). This decrease was more prominent in M694V mutation carriers. Plasma miRNA-155 levels of FMF patients were lower in remission period (p=0.03).
Conclusion: Our findings showed significant alterations in the plasma expression of miRNA-155 and miRNA-204 in FMF patients compared to HCs. Our data suggest that miRNA-155 and miRNA-204 may be related to the pathogenesis of FMF. Further comprehensive and functional researches may help to clarify the role of miRNAs in FMF and elucidate the pathogenesis of the disease.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Vol. 35 No. 1 (2020): The Archives of Rheumatology
Pages
052-059
History
Published Online
March 31, 2020
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
1
Ferhat DEMİR
Department of Pediatric Rheumatology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
2
Alper Han ÇEBİ
Department of Medical Genetics, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
3
Mukaddes KALYONCU
Department of Pediatric Rheumatology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
Cite this Article
Ferhat DEMİR, Alper Han ÇEBİ, & Mukaddes KALYONCU. (2020). Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. Archives of Rheumatology, 35(1), 052–059. https://doi.org/10.5606/ArchRheumatol.2020.7414
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