Published In
Archives of Rheumatology
Volume: 34 Issue: 4, December 2019
Pages: 419-425
History
Published Online: December 31, 2019
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tuba KOCA
Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
Burhan KOÇYİĞİT
Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
Muhammet SEYİTHANOĞLU
Department of Clinic Biochemistry, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
Ejder BERK
Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
Tuba KOCA, Burhan KOÇYİĞİT, Muhammet SEYİTHANOĞLU, & Ejder BERK. (2019). The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia. Archives of Rheumatology, 34(4), 419–425. https://doi.org/10.5606/ArchRheumatol.2019.7236
Abstract
Objectives: This study aims to analyze the G-protein coupled estrogen receptor (GPER/GPR30) activity in patients with fibromyalgia syndrome (FMS).
Patients and methods: We enrolled 40 female patients with FMS (mean age 42.9±11.2 years; range, 18 to 64 years) diagnosed according to the 2010 American College of Rheumatology classification criteria and 30 age- and body mass index-matched female healthy controls (mean age 43.7±13.6 years; range, 19 to 64 years). Sex hormones of patients (morning) including estradiol, follicle stimulating hormone, luteinizing hormone, and prolactin (PRL) were recorded. FMS severity was assessed by Fibromyalgia Impact Questionnaire (FIQ). Serum GPER levels were measured by using a quantitative sandwich enzyme-linked immunosorbent assay method with a commercial kit.
Results: G-protein coupled estrogen receptor levels were 0.11 (0.02-0.9) ng/mL in the FMS patients and 0.059 (0.01-0.13) ng/mL in controls, with a statistically significant difference (p=0.037). GPER levels were positively correlated with age and negatively correlated with PRL, while they were not correlated with FIQ. Differential diagnosis for FMS with receiver operating characteristic (ROC) analysis for the serum GPER levels was statistically significant (area under the ROC curve: 0.653, confidence interval: 0.522-0.785, p=0.029). High values indicated FMS, with a threshold of >0.075, sensitivity of 60%, and specificity of 60%.
Conclusion: The GPER levels of FMS patients were higher than those of the controls. Thus, GPER levels may be considered as a biomarker in the diagnosis of FMS independent of disease severity.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Vol. 34 No. 4 (2019): The Archives of Rheumatology
Pages
419-425
History
Published Online
December 31, 2019
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
1
Tuba KOCA
Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
2
Burhan KOÇYİĞİT
Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
3
Muhammet SEYİTHANOĞLU
Department of Clinic Biochemistry, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
4
Ejder BERK
Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey
Cite this Article
Tuba KOCA, Burhan KOÇYİĞİT, Muhammet SEYİTHANOĞLU, & Ejder BERK. (2019). The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia. Archives of Rheumatology, 34(4), 419–425. https://doi.org/10.5606/ArchRheumatol.2019.7236
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